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  5. Tocris Bioscience™ JTE 607 Dihydrochloride

Tocris Bioscience™ JTE 607 Dihydrochloride
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Catalog No. 518550
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Catalog No. 518550 Supplier Tocris Bioscience™ Supplier No. 5185/50
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Description

Cytokine release inhibitor; anti-inflammatory

JTE 607 dihydrochloride is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3; Kd = 370 nM at human CPSF3). Treatment of A-673 cells with JTE 607 results in inhibition of mRNA cleavage and accumulation of nuclear R-loops. JTE 607 induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model. JTE 607 inhibits cytokine release and inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. In a rat model of lung injury, JTE 607 reduces proinflammatory cytokine-release and attenuates lung permeability.

Specifications

Chemical Name or Material JTE 607 dihydrochloride
CAS 188791-09-5
Synonym N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Quantity 50 mg
Solubility Soluble to 100mM in water and to 100mM in DMSO
Molecular Formula C25H31Cl2N3O5·2HCl
Formula Weight 597.36
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >98%

Research Use Only. Not For Human or Veterinary Use

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