R&D Systems™ Pan Caspase Inhibitor Z-VAD-FMK

Description

Used as cell-permeable, irreversible inhibitor of caspase activity. R&D Systems Pan Caspase Inhibitor Z-VAD-FMK binds to the active site of activated proteases irreversibly and inhibits apoptosis.

• Fluoromethyl ketone (FMK)-derivatized peptides are useful tools for studying caspase activity
• Used in tissue cultures to inhibit apoptosis at final working concentrations of 50nM to 100μM
• Regulated by a variety of stimuli, including APAF1, CFLAR/FLIP, NOL3/ARC, IAP, BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin and BIRC7/Livin

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Specifications

• Content And Storage: Store the unopened product at -20 to -70° C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
• Quantity: 1 mg
• Product Type: Pan Caspase
• Molecular Weight (g/mol): 467Da
• Inhibitors: Z-VAD-FMK
• Form: Lyophilized

For research use only. Not for use in diagnostic procedures