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Rabbit anti-beta-Catenin, Polyclonal, Novus Biologicals™
SDP

Catalog No. NBP22947602 Shop All R&D Systems Products
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0.2 mg
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NBP22947602 0.2 mg
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Catalog No. NBP22947602 Supplier Novus Biologicals Supplier No. NBP2294760.2MG

Specifications

Antigen beta-Catenin
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
Classification Polyclonal
Concentration 0.2mg/mL
Conjugate Unconjugated
Dilution Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry 1-2ug/ml, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 1-2ug/500ug protein lysate, Immunohistochemistry-Paraffin 1-2ug/ml
Formulation PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Accession No. P35222
Gene Alias beta 1 (88kD), beta-catenin, catenin (cadherin-associated protein), beta 1, 88kDa, catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
Gene Symbols CTNNB1
Host Species Rabbit
Immunogen A synthetic peptide from the middle of beta-Catenin protein
Molecular Weight of Antigen 92 kDa
Purification Method Protein A purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Cancer, Cellular Markers, Extracellular Matrix, Neuroscience, Phospho Specific, Stem Cell Signaling Pathway, Wnt Signaling Pathway
Primary or Secondary Primary
Gene ID (Entrez) 1499
Test Specificity Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
Target Species Human, Mouse
Content And Storage Store at 4C.
Form Purified
Isotype IgG
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