Rad6 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A300281A

Catalog No. 50-155-7278

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Rat, D. melanogaster, Bovine and Rabbit

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at ′Lys-120′ to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes ′Lys-11′, as well as ′Lys-48′-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

Specifications

• Antigen: Rad6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBE2A
• Gene Alias: HHR6A, MRXS30, MRXSN, RAD6A, UBC2, HR6A, RAD6 homolog A, ubiquitin carrier protein A, ubiquitin-conjugating enzyme E2 A, ubiquitin-conjugating enzyme E2A (RAD6 homolog), ubiquitin-protein ligase A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22209, 7319
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/ml
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene Accession No.: P49459, Q9Z255
• Gene Symbols: UBE2A
• Immunogen: N-terminus
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG