RAF1/c-RAF Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-156-0594	Bethyl Laboratories, Inc A301519AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine and Orangutan

Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noo syndrome 5 and LEOPARD syndrome 2.

Specifications

• Antigen: RAF1/c-RAF
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: CRAF, NS5, Raf-1, c-Raf
• Immunogen: Between 598 and 648
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: RAF1

• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: P04049, Q99N57
• Gene ID (Entrez): 110157, 5894
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody