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RAF1/c-RAF Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7140927
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Catalog No. Quantity
50-156-0594 20 μL
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Catalog No. 50-156-0594 Supplier Bethyl Laboratories, Inc Supplier No. A301519AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine and Orangutan

Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noo syndrome 5 and LEOPARD syndrome 2.

Specifications

Antigen RAF1/c-RAF
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene RAF1
Gene Accession No. P04049, Q99N57
Gene Alias CRAF, NS5, Raf-1, c-Raf
Gene Symbols RAF1
Host Species Rabbit
Immunogen Between 598 and 648
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110157, 5894
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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