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Tocris Bioscience™ Rapamycin
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Catalog No. 12921
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Quantity:
1 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

mTOR inhibitor; immunosuppressant

Rapamycin is a antifungal and immunosuppressant. Specific inhibitor of mTOR (mammalian target of Rapamycin). Complexes with FKBP-12 and binds mTOR inhibiting its activity. Inhibits interleukin-2-induced phosphorylation and activation of p70 S6 kinase. Induces autophagy in yeast and mammalian cell lines. Drives hPSC differentiation to mesendoderm and blood progenitor cells. Also used as a chemical dimerizer; rapamycin and GA3-AM (Cat. No. 5407) chemically inducible dimerization systems are orthogonal. Inhibits MERS-CoV infection of Huh7 cells in a plaque reduction assay. Enhances lentiviral transduction of hematopoietic stem cells.

Chemical Identifiers

CAS 53123-88-9
Molecular Formula C51H79NO13

Specifications

Quantity 1 mg
Formula Weight 914.18
Product Type Rapamycin
Purity 98%
Molecular Weight (g/mol) 914.187
Chemical Name or Material Rapamycin

Safety and Handling

Recommended Storage Desiccate at -20°C
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