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RB1 Antibody (172C1094), DyLight 488 - (cleaved), Novus Biologicals™
SDP

Catalog No. NB10056598G Shop All R&D Systems Products
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NB10056598G 0.1 mL
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Catalog No. NB10056598G Supplier Novus Biologicals Supplier No. NB10056598G

Description

Mouse Monoclonal Antibody

RB1 Monoclonal specifically detects RB1 in Human, Mouse samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Knockdown Validated.

Specifications

Antigen cleaved Retinoblastoma 1
Applications Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen), KnockDown
Classification Monoclonal
Clone 172C1094
Conjugate DyLight 488
Dilution Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Knockdown Validated
Gene Alias OSRC, osteosarcoma, p105-Rb, pp110, pRb, Rb, retinoblastoma 1, retinoblastoma suspectibility protein, retinoblastoma-associated protein
Gene Symbols RB1
Host Species Mouse
Immunogen A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.
Purification Method Protein G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Cancer, Cell Cycle and Replication, Transcription Factors and Regulators, Tumor Suppressors
Primary or Secondary Primary
Gene ID (Entrez) 5925
Test Specificity The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb. In camptothecin treated HL60, an ∼68 kDa band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
Target Species Human, Mouse
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG1
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