RB1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-5988	Proteintech Group Inc 100482IG150UL	150 μL

Description

This antibody is a rabbit polyclonal antibody raised against human RB1 fusion protein.

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia. Phosphorylation of Rb at S608 depends on CDK4.

Specifications

• Antigen: RB1
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: P06400, P13405
• Gene ID (Entrez): 19645, 5925
• Immunogen: RB1 Fusion Protein Ag0006
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: RB1

• Concentration: 1 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: OSRC, p105 Rb, pp110, pRb, RB, RB1, retinoblastoma 1
• Gene Symbols: RB1
• Isotype: IgG
• Purification Method: Protein A
• Product Type: Antibody