Respiratory Syncytial Virus Glycoprotein F Antibody (11-2-F3), HRP, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP250412H

Catalog No. NBP250412H

Description

Respiratory Syncytial Virus Glycoprotein F Monoclonal specifically detects Respiratory Syncytial Virus Glycoprotein F in Virus samples. It is validated for Western Blot, ELISA.

Specifications

• Antigen: Respiratory Syncytial Virus Glycoprotein F
• Classification: Monoclonal
• Conjugate: HRP
• Formulation: PBS with No Preservative
• Immunogen: Gradient-purified RSF-44 virus (subgroup A) UV inactivated for 20 minutes at 20C
• Quantity: 0.1 mL
• Research Discipline: Virology Bacteria and Parasites
• Test Specificity: This antibody reacts with the RS virus fusion glycoprotein F (also named VP70 or F0 protein), specifically to a subunit of the F protein, F1 (also named VGP48 or 48kDa), from both subgroups A and B of RS virus.This antibody has a high neutralising activity; 90% plaque neutralization titre of 102.2 (Gimenez et al 1996). This property makes it potentially useful for the preparation of reagents for prevention and/or therapeutic use (for example, vaccines or new-generation of man-made antibodies). The characterisation of the epitope of this antibody which induce high neutralising activity will be useful for the preparation of reagents (for example vaccine) to prevent RS virus infection. A RS virus vaccine is not yet available. A vaccine could be used to increase the maternal immunity to RS virus, which would then be passed to the newborn baby to provide passive immunity.The further characterisation of the epitope recognised by this antibody, which possesses a high neutralising activity, will be useful for the preparation of reagents to prevent RS virus infection. New-generation man-made antibodies, based on the 11-2-F3 antibody, could complement the effectiveness of polivizumab (Synagis), which is used to prevent but not treat established RS virus infections (Nature Biotechnology, 2013, 31, 952).
• Content And Storage: Store at 4C in the dark.
• Isotype: IgG1

• Applications: Western Blot, ELISA
• Clone: 11-2-F3
• Dilution: Western Blot, ELISA
• Host Species: Mouse
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Virus
• Form: Purified