Invitrogen™ RNASEH2A Polyclonal Antibody

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIPA5119399	Invitrogen™ PA5119399	200 μL
PIPA5121855	Invitrogen™ PA5121855	20 μL

Description

RNASEH2A Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.

Specifications

• Antigen: RNASEH2A
• Content And Storage: -20°C
• Classification: Polyclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: RNASEH2A
• Gene Alias: 2400006P09Rik; AGS4; Aicardi-Goutieres syndrome 4 protein; hypothetical protein LOC512830; hypothetical protein MGC56307; JUNB; ribonuclease H2 subunit A; ribonuclease H2, large subunit; ribonuclease H2, subunit A; ribonuclease HI; ribonuclease HI large subunit; Ribonuclease HI subunit A; ribonuclease HI, large subunit; RNase H(35); RNase H2 subunit A; RNase HI large subunit; Rnaseh2a; RNASEHI; RNHIA; RNHL; zgc:56307
• Gene Symbols: RNASEH2A
• Primary or Secondary: Primary
• Purification Method: Antigen Affinity Chromatography

• Concentration: 0.5 mg/mL
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300
• Gene Accession No.: O75792
• Gene ID (Entrez): 10535
• Immunogen: Recombinant protein Ribonuclease H2 Subunit A. The antigen corresponds to amino acid range 1-299 of the target protein.
• Product Type: Antibody