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Tocris Bioscience™ Ro 08-2750
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Catalog No. 22721
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Catalog No. Quantity
22-721 1 mg
22-721-0 10 mg
22-725-0 50 mg
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Catalog No. 22-721 Supplier Tocris Bioscience™ Supplier No. 2272/1
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Description

Inhibits NGF binding to p75NTR and TrkA

Non-peptide inhibitor of NGF that binds the NGF dimer (KD ∽ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation.

Chemical Identifiers

CAS 37854-59-4
Molecular Formula C13H10N4O3

Specifications

Quantity 1 mg
Formula Weight 270.24
Purity >96%
Molecular Weight (g/mol) 270.248
Chemical Name or Material Ro 08-2750

Safety and Handling

Recommended Storage Store at -20°C
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