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Tocris Bioscience™ Ro 31-8220 mesylate
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Catalog No. 200210
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Protein kinase inhibitor

Protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range. Induces protein-protein interaction between mutant SMAD4R361H and SMAD3, leading to reactivation of dormant SMAD4R361H-mediated transcriptional activity and restoration of TGF-β-induced tumor suppression activity in SMAD4 mutant cancer cells.

Chemical Identifiers

CAS 138489-18-6
Molecular Formula C26H27N5O5S2

Specifications

Quantity 10 mg
Formula Weight 553.65
Purity >97%
Molecular Weight (g/mol) 553.652
Chemical Name or Material Ro 31-8220 mesylate

Safety and Handling

Recommended Storage Desiccate at -20°C
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