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  8. Ro 61-8048, Tocris Bioscience™

Ro 61-8048, Tocris Bioscience™

Catalog Number 325450
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
199666-03-0
C17H15N3O6S2
421.442
NDPBMCKQJOZAQX-UHFFFAOYSA-N
3,4-dimethoxy-n-4-3-nitrophenyl thiazol-2-yl benzenesulfonamide, 3,4-dimethoxy-n-4-3-nitrophenyl-1,3-thiazol-2-yl benzenesulfonamide, 3,4-dimethoxy-n-4-3-nitro-phenyl-thiazol-2-yl-benzenesulfonamide, 7zr, ro hplc, 3,4-dimethoxy-n-4-3-nitrophenyl-1,3-thiazol-2-y, 3,4-dimethoxy-n-4-3-nitrophenyl-2-thiazolyl-benzenesulfonamide, 3,4-dimethoxy-n-4-3-nitrophenyl-2-thiazolyl benzenesulfonamide, 3,4-dimethoxy-n-4-3-nitrophenyl-1,3-thiazol-2-yl benzene-1-sulfonamide
5282337
CHEBI:34953
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC(=CC=C3)[N+](=O)[O-])OC
This item is not returnable. View return policy
199666-03-0
C17H15N3O6S2
421.442
NDPBMCKQJOZAQX-UHFFFAOYSA-N
3,4-dimethoxy-n-4-3-nitrophenyl thiazol-2-yl benzenesulfonamide, 3,4-dimethoxy-n-4-3-nitrophenyl-1,3-thiazol-2-yl benzenesulfonamide, 3,4-dimethoxy-n-4-3-nitro-phenyl-thiazol-2-yl-benzenesulfonamide, 7zr, ro hplc, 3,4-dimethoxy-n-4-3-nitrophenyl-1,3-thiazol-2-y, 3,4-dimethoxy-n-4-3-nitrophenyl-2-thiazolyl-benzenesulfonamide, 3,4-dimethoxy-n-4-3-nitrophenyl-2-thiazolyl benzenesulfonamide, 3,4-dimethoxy-n-4-3-nitrophenyl-1,3-thiazol-2-yl benzene-1-sulfonamide
5282337
CHEBI:34953
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC(=CC=C3)[N+](=O)[O-])OC

Description

Potent kynurenine 3-monooxygenase (KMO) inhibitor

Ro 61-8048 is a potent and competitive kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (Ki = 4.8 nM, IC50 = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities. Ro 61-8048 decreases nicotine self-administration in vivo. Ro 61-8048 prevents post-operative brain edema and consequent neuronal apoptosis in a rat model of surgically induced brain injury.
Quantity 50 mg
Formula Weight 421.45
Percent Purity >99%
Chemical Name or Material Ro 61-8048

Safety and Handling

Recommended Storage Store at +4°C
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