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Tocris Bioscience™ Roscovitine
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Catalog No. p-7121272
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Quantity:
10 mg
50mg
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This item is not returnable. View return policy

Description

Potent, selective cyclin-dependent kinase inhibitor

Cyclin-dependent kinase (cdk) inhibitor. Displays sub-micromolar inhibition of cdk1, cdk2, cdk5, cdk7 and cdk9 (reported IC50 values range from 0.16 - 0.28 μM for cdk5 to 0.8 μM for cdk7). Selective for cdks over a wide range of related kinases including ERK1 and ERK2. Arrests L1210 cells in G1 phase. Inhibits phosphorylation of vimentin in vivo. Antimitotic.

Specifications

CAS 186692-46-6
Synonym roscovitine, seliciclib, r-roscovitine, rosco, 2-r-1-ethyl-2-hydroxyethylamino-6-benzylamino-9-isopropylpurine, unii-0es1c2kq94, insolution™ roscovitine, chembl14762, bmk1-e12
Quantity 10 mg
Molecular Formula C19H26N6O
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