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        Tocris Bioscience™ Rottlerin
    
    
    
    
    
    
    
    
    
    
        
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                                Quantity:
                            
                        
                        
                            
                                10 mg
                            
                        
                            
                                50 mg
                            
                        
                    Description
Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.
                        
                        
                        
                        
                        
                        
                        
                        
                        
                    
                
                
                    
                
                
    
                
    
            Specifications
Specifications
| Quantity | 50 mg | 
| Formula Weight | 516.55 | 
| Purity | >98% | 
| Molecular Weight (g/mol) | 516.546 | 
| Chemical Name or Material | Rottlerin | 
Safety and Handling
| Recommended Storage | Store at +4°C | 
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