Rubicon Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-3421	Proteintech Group Inc 214441AP150UL	150 μL

Description

Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation. Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex. Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines.

Specifications

• Antigen: Rubicon
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q80U62, Q92622
• Gene ID (Entrez): 100502698, 303885, 9711
• Immunogen: Rubicon Fusion Protein Ag13715
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: RUBCN

• Concentration: 0.47 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: Baron, KIAA0226, RUBCN, Rubicon
• Gene Symbols: Rubcn
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody