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RWJ 67657, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
10mg
This item is not returnable. View return policy
215303-72-3
C27H24FN3O
425.507
QSUSKMBNZQHHPA-UHFFFAOYSA-N
4-4-4-fluorophenyl-1-3-phenylpropyl-5-pyridin-4-yl-1h-imidazol-2-yl but-3-yn-1-ol,4-4-4-fluorophenyl-1-3-phenylpropyl-5-4-pyridinyl-1h-imidazol-2-yl-3-butyn-1-ol,4-4-fluorophenyl-2-4-hydroxy-1-butynyl-1-3-phenylpropyl-5-4-pyridyl imidazole,4-4-4-fluorophenyl-1-3-phenylpropyl-5-4-pyridyl imidazol-2-yl but-3-yn-1-ol,4-4-4-fluorophenyl-1-3-phenylpropyl-5-4-pyridinyl-1h-imidazol-2-yl-3-butyn-1-ol,3-butyn-1-ol, 4-4-4-fluorophenyl-1-3-phenylpropyl-5-4-pyridinyl-1h-imidazol-2-yl,3-butyn-1-ol, 4-4-4-fluorophenyl-1-3-phenylpropyl-5-4-pyridinyl-1h-imidazol-2-yl,d06ozj,4-4-4-fluorophenyl-1-3-phenylpropyl-5-pyridin-4-ylimidazol-2-yl but-3-yn-1-ol,4-4-4-fluoro-phenyl-1-3-phenyl-propyl-5-pyridin-4-yl-1h-imidazol-2-yl-but-3-yn-1-ol
3008319
4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-pyridin-4-ylimidazol-2-yl]but-3-yn-1-ol
C1=CC=C(C=C1)CCCN2C(=NC(=C2C3=CC=NC=C3)C4=CC=C(C=C4)F)C#CCCO
This item is not returnable. View return policy
215303-72-3
C27H24FN3O
425.507
QSUSKMBNZQHHPA-UHFFFAOYSA-N
4-4-4-fluorophenyl-1-3-phenylpropyl-5-pyridin-4-yl-1h-imidazol-2-yl but-3-yn-1-ol,4-4-4-fluorophenyl-1-3-phenylpropyl-5-4-pyridinyl-1h-imidazol-2-yl-3-butyn-1-ol,4-4-fluorophenyl-2-4-hydroxy-1-butynyl-1-3-phenylpropyl-5-4-pyridyl imidazole,4-4-4-fluorophenyl-1-3-phenylpropyl-5-4-pyridyl imidazol-2-yl but-3-yn-1-ol,4-4-4-fluorophenyl-1-3-phenylpropyl-5-4-pyridinyl-1h-imidazol-2-yl-3-butyn-1-ol,3-butyn-1-ol, 4-4-4-fluorophenyl-1-3-phenylpropyl-5-4-pyridinyl-1h-imidazol-2-yl,3-butyn-1-ol, 4-4-4-fluorophenyl-1-3-phenylpropyl-5-4-pyridinyl-1h-imidazol-2-yl,d06ozj,4-4-4-fluorophenyl-1-3-phenylpropyl-5-pyridin-4-ylimidazol-2-yl but-3-yn-1-ol,4-4-4-fluoro-phenyl-1-3-phenyl-propyl-5-pyridin-4-yl-1h-imidazol-2-yl-but-3-yn-1-ol
3008319
4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-pyridin-4-ylimidazol-2-yl]but-3-yn-1-ol
C1=CC=C(C=C1)CCCN2C(=NC(=C2C3=CC=NC=C3)C4=CC=C(C=C4)F)C#CCCO

Description

Potent, selective p38α and p38β inhibitor

Selective p38α and p38β inhibitor (IC 50 values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases. Potently inhibits TNF-α and IL-1β release (IC 50 values are 3 and 11 nM respectively) and suppresses HIV-1 replication in T cells in vitro. Displays cardioprotective and anti-inflammatory activity in vivo. Orally active.

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Quantity 10mg
Formula Weight 425.5
Percent Purity >98%
Chemical Name or Material RWJ 67657

Safety and Handling

Recommended Storage : Store at Room Temperature