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S100A8 Monoclonal Antibody (CF-145), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
$1562.00
Specifications
| Antigen | S100A8 |
|---|---|
| Clone | CF-145 |
| Concentration | 0.5 mg/mL |
| Applications | Immunohistochemistry (Paraffin), Western Blot |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
14-974-537
|
Invitrogen™
14974537 |
2 mg |
Each of 1 for $1,562.00
|
|
|||||
Description
The MAb CF-145 recognizes human S100A8. S100A8, also known as migration inhibitory factor-related protein 8 (MRP-8) or Calgranulin-A, is a calcium binding protein and member of the S100 family of proteins. S100A8 is expressed by neutrophils, monocytes, macrophages, granulocytes, and epithelial cells during dermatoses, such as psoriasis. S100A8 forms a heterodimer with S100A9, which together is known as calprotectin. S100A8 has antimicrobial and pro-apoptotic properties and is a pro-inflammatory mediator in acute and chronic inflammation. Levels of S100A8 are elevated in patients with various inflammatory disorders such as cystic fibrosis, rheumatoid arthritis, and chronic bronchitis. Upregulation of S100A8 is also observed in many tumors, including skin, breast, colon, pancreatic, and ovarian cancers.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.Specifications
| S100A8 | |
| 0.5 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| 6279 | |
| Primary | |
| 4°C | |
| S100A8 |
| CF-145 | |
| Immunohistochemistry (Paraffin), Western Blot | |
| Unconjugated | |
| Mouse | |
| Human | |
| P05109 | |
| IgG2b κ | |
| Affinity Chromatography | |
| Antibody |
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