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S100A9 Antibody (47-8D3 (DF3973)), Alexa Fluor™ 532, Novus Biologicals™
SDP

Catalog No. NB007547 Shop All R&D Systems Products
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NB007547 0.1 mL
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Catalog No. NB007547 Supplier Novus Biologicals Supplier No. NBP247980AF532
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Description

Mouse Monoclonal Antibody

S100A9 Monoclonal specifically detects S100A9 in Human, Mouse, Rat samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

Antigen S100A9
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone 47-8D3 (DF3973)
Conjugate Alexa Fluor 532
Dilution Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias CAGBMigration inhibitory factor-related protein 14, calgranulin B, calgranulin-B, Calprotectin L1H subunit, CFAGMRP-14,60B8AG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14Leukocyte L1 complex heavy chain, NIF, P14, protein S100-A9, S100 calcium binding protein A9, S100 calcium binding protein A9 (calgranulin B), S100 calcium-binding protein A9, S100 calcium-binding protein A9 (calgranulin B)
Gene Symbols S100A9
Host Species Mouse
Immunogen Human peripheral blood monocyte components (Uniprot: P06702)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Cancer, Immunology, Innate Immunity, Signal Transduction, Tyrosine Kinases
Primary or Secondary Primary
Test Specificity This monoclonal antibody stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffers cells of the skin. It also stains the mantle zone B-lymphocytes of the lymph node and spleen, spermatogonia, and chief cells of the stomach. S100A9 is expressed by macrophages in acutely inflamed tissues and in chronic inflammation. It is detected in peripheral blood leukocytes, in neutrophils and granulocytes. It is present at sites of vascular inflammation. S100A9 is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a Calcium-binding protein. It has antimicrobial activity towards bacteria and fungi. It is important for resistance to invasion by pathogenic bacteria. It up-regulates transcription of genes that are under the control of NF-kappa-B. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. It plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1.
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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