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Tocris Bioscience™ SB 216763
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Catalog No. 16161
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16-161 1 mg
16-161-0 10 mg
16-165-0 50 mg
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Catalog No. 16-161 Supplier Tocris Bioscience™ Supplier No. 1616/1
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Description

Potent, selective GSK-3 inhibitor

Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 = 34.3 nM for GSK-3α). Equally effective at inhibiting human GSK-3α and GSK-3β. Exhibits minimal activity against 24 other protein kinases (IC50 >10 μM). Stimulates glycogen synthesis in liver cells, and induces β-catenin-dependent gene transcription. Neuroprotective; also reduces pulmonary inflammation and fibrosis in a mouse model. Shown to maintain mouse embryonic stem cells in a pluripotent state.

Chemical Identifiers

CAS 280744-09-4
Molecular Formula C19H12Cl2N2O2

Specifications

Quantity 1 mg
Formula Weight 371.22
Purity >98%
Molecular Weight (g/mol) 371.217
Chemical Name or Material SB 216763

Safety and Handling

Recommended Storage Store at Room Temperature
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