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SB 431542, Tocris Bioscience™
GSA_VA

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

$162.60 - $327.00

Specifications

CAS 301836-41-9
Molecular Formula C22H16N4O3
Synonym 4-5-benzo 1,3 dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl-benzamide
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
16-141
GSA_VA
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Tocris Bioscience
1614/1
1 mg
Each for $162.60
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16-141-0
GSA_VA
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Tocris Bioscience
1614/10
10 mg
Each for $327.00
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Description

Description

Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.

SB 431542 synthesized to cGMP guidelines also available.

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Specifications

Specifications

301836-41-9
C22H16N4O3
4-5-benzo 1,3 dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl-benzamide
Safety and Handling

Safety and Handling

Recommended Storage : Store at Room Temperature

SDS
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