DescriptionPotent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.
SB 431542 synthesized to cGMP guidelines also available.
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|4-5-benzo 1,3 dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl-benzamide|
Safety and Handling
Recommended Storage : Store at Room Temperature
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