Selective NOP receptor antagonist (Ki values are 0.33, 57.6, 160.5 and 2109nM for NOP,µ-, κ- and δ-receptors respectively). Antagonizes the pronociceptive action of nociceptin (Cat. No. 0910) in an acute pain model. Potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model.
Chemical Name: 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride
CAS Number: 371980-94-8
Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
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