Tocris™ SC 144 hydrochloride

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

Manufacturer: Tocris™ 4963/10

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Catalog No. 49-631-0

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For Research Use Only


    Inhibitors SC 144 hydrochloride
    Purity >99
    Molecular Weight 358.76
    Quantity 10mg
    Product Type SC 144 hydrochloride

    Inhibitor of gp130 (IC50 = 0.72µM); blocks cytokine-triggered gp130 signaling. Induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. Delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.

    • Chemical Name: 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride
    • Formula: C16H11FN6O.HCl
    • CAS Number: 917497-70-2
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

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