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Tocris™ SC 144 hydrochloride

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

Manufacturer:  Tocris™ 4963/10

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Catalog No. 49-631-0


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Disclaimers:

For Research Use Only


Specifications

Description

Inhibitor of gp130 (IC50 = 0.72µM); blocks cytokine-triggered gp130 signaling. Induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. Delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.
  • Chemical Name: 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride
  • Formula: C16H11FN6O.HCl
  • CAS Number: 917497-70-2
  • Solubility: Soluble to 100mM in DMSO
  • Purity: >99
Description & Specifications

Specifications

SC 144 hydrochloride
>99
10mg
SC 144 hydrochloride
358.76
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