Invitrogen™ SCN5A Polyclonal Antibody

Catalog No.	Quantity
PIPA5110346	100 μL

Catalog No. PIPA5110346 Supplier Invitrogen™ Supplier No. PA5110346

Description

Rabbit Polyclonal Antibody

Immunogen sequence: YVMSENFSRP LGPPSSSSIS STSFPPSYDS VTRATSDNLQ VRGSDYSHSE DLADFPPSPD RDRESIV.

Scn5a is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Scn5a is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in Scn5a are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms of Scn5a. Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. Expression of Scn5a is also detected in lymphocytes, glia, and fibroblasts. Further, Scn5a mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Scn5a forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Functionally, Scn5a is responsible for the initial upstroke of the action potential and the channel inactivation is regulated by intracellular calcium levels. Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. Scn5a are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Diseases associated with SCN5A include Long Qt Syndrome-3 and Brugada Syndrome 1.

Specifications

• Antigen: SCN5A
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.74 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene: SCN5A
• Gene Accession No.: Q14524, Q9JJV9
• Gene Alias: cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2; CDCD2VF1; CIN5; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; HH1CMD1E; ICCD; IVF; LQT3; LQT3SSS1CMPD2; mH1; Nav1.5; Nav1.5c; PFHB1; RATRSKM2X; RH1; RSkM2; RSKM2X; SCAL; Scn2x; SCN5A; SkM1; SkM2; sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type 5 subunit alpha; sodium channel protein type V subunit alpha; sodium channel voltage-gated type V alpha polypeptide; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type V, alpha; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; sodium voltage-gated channel alpha subunit 5; SSS1; VF1; voltage-gated sodium channel Nav1.5c; voltage-gated sodium channel subunit alpha Nav1.5
• Gene Symbols: SCN5A
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1950-2016 of human SCN5A (NP_932173.1).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20271, 6331
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG