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  7. SD 208, Tocris Bioscience™

SD 208, Tocris Bioscience™

Catalog Number 326910
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
627536-09-8
C17H10ClFN6
352.76
MFCD11519969
BERLXWPRSBJFHO-UHFFFAOYSA-N
alk5 inhibitor v, 2-5-chloro-2-fluorophenyl-n-pyridin-4-yl pteridin-4-amine, 2-5-chloro-2-fluorophenyl pteridin-4-yl pyridin-4-yl-amine, 2-5-chloro-2-fluorophenyl-n-pyridin-4-ylpteridin-4-amine, 2-5-chloro-2-fluorophenyl pteridin-4-yl pyridin-4-yl amine, transforming growth factor-beta type i receptor kinase inhibitor v, d0v8ac, tgf-, a ri kinase inhibitor v, tgf-ri kinase inhibitor v, 2-5-chloro-2-fluorophenyl-4-4-pyridyl amino pteridine
10316032
2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
FC1=C(C=C(Cl)C=C1)C1=NC(NC2=CC=NC=C2)=C2N=CC=NC2=N1
This item is not returnable. View return policy
627536-09-8
C17H10ClFN6
352.76
MFCD11519969
BERLXWPRSBJFHO-UHFFFAOYSA-N
alk5 inhibitor v, 2-5-chloro-2-fluorophenyl-n-pyridin-4-yl pteridin-4-amine, 2-5-chloro-2-fluorophenyl pteridin-4-yl pyridin-4-yl-amine, 2-5-chloro-2-fluorophenyl-n-pyridin-4-ylpteridin-4-amine, 2-5-chloro-2-fluorophenyl pteridin-4-yl pyridin-4-yl amine, transforming growth factor-beta type i receptor kinase inhibitor v, d0v8ac, tgf-, a ri kinase inhibitor v, tgf-ri kinase inhibitor v, 2-5-chloro-2-fluorophenyl-4-4-pyridyl amino pteridine
10316032
2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
FC1=C(C=C(Cl)C=C1)C1=NC(NC2=CC=NC=C2)=C2N=CC=NC2=N1

Description

Potent ATP-competitive TGF-βRI inhibitor

Potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50 = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. Also promotes an antiglioma immune response. Ameliorates germinal matrix hemorrhage-induced neurological deficits in neonatal rats.
Quantity 10 mg
Formula Weight 352.75
Percent Purity >98%
Chemical Name or Material SD 208

Safety and Handling

Recommended Storage Store at Room Temperature
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