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Serpin A3/alpha 1-Antichymotrypsin Antibody (AACT/1451), DyLight 594, Novus Biologicals™
SDP

Catalog No. NB008047 Shop All R&D Systems Products
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NB008047 0.1 mL
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Catalog No. NB008047 Supplier Novus Biologicals Supplier No. NBP254339DL594
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Description

Mouse Monoclonal Antibody

Serpin A3/alpha 1-Antichymotrypsin Monoclonal specifically detects Serpin A3/alpha 1-Antichymotrypsin in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Serpin A3/alpha 1-Antichymotrypsin
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone AACT/1451
Conjugate DyLight 594
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias AACTMGC88254, ACTGIG25, alpha-1-antichymotrypsin, antitrypsin), member 3, Cell growth-inhibiting gene 24/25 protein, growth-inhibiting protein 24, growth-inhibiting protein 25, member 3, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, serine (or cysteine) proteinase inhibitor, clade A, member 3, Serpin A3, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
Gene Symbols SERPINA3
Host Species Mouse
Immunogen Recombinant human Serpin A3/alpha 1-Antichymotrypsin protein fragment (around aa 49-187) (exact sequence is proprietary) (Uniprot: P01011)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Breast Cancer, Cancer
Primary or Secondary Primary
Test Specificity It recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). AACT is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACT antibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1
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