Tocris SGI 1027
DNA methyltransferase inhibitor
Manufacturer: Tocris 5155/10
DescriptionDNA methyltransferase inhibitor. Inhibits the mammalian DNA methyltransferases DNMT3B, DNMT3A and DNMT1 (IC50 values are 7.5, 8 and 12.5 µM with Poly(dl-dC) as the substrate). Reactivates silenced tumor suppressor genes by reducing CpG island hypermethylation.
- Chemical Name: N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
- Formula: C27H23N7O
- CAS Number: 1020149-73-8
- Solubility: Soluble to 50mM in DMSO
- Purity: >99
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