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SIGLEC7 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501729106 Shop All Proteintech Group Inc Products
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50-172-9106 150 μL
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Catalog No. 50-172-9106 Supplier Proteintech Group Inc Supplier No. 139391AP150UL
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Description

Rabbit Polyclonal Antibody

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Specifications

Antigen SIGLEC7
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.29 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene SIGLEC7
Gene Accession No. Q9Y286
Gene Alias AIRM 1, AIRM1, CD328, CDw328, D siglec, p75, p75/AIRM1, QA79, QA79 membrane protein, SIGLEC 7, SIGLEC7
Gene Symbols SIGLEC7
Host Species Rabbit
Immunogen SIGLEC7 Fusion Protein Ag4220
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27036
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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