SIGLEC7 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-9106	Proteintech Group Inc 139391AP150UL	150 μL

Description

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Specifications

• Antigen: SIGLEC7
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q9Y286
• Gene ID (Entrez): 27036
• Immunogen: SIGLEC7 Fusion Protein Ag4220
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SIGLEC7

• Concentration: 0.29 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: AIRM 1, AIRM1, CD328, CDw328, D siglec, p75, p75/AIRM1, QA79, QA79 membrane protein, SIGLEC 7, SIGLEC7
• Gene Symbols: SIGLEC7
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody