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SIP1 Monoclonal Antibody (6E5), Active Motif™
SDP

Catalog No. 501993137
Encompass
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50-199-3137 100 μg
50-199-3138 10 μg
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Catalog No. 50-199-3137 Supplier Active Motif Supplier No. 61095
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Description

Mouse Monoclonal Antibody

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

Specifications

Antigen SIP1
Applications Western Blot
Classification Monoclonal
Clone 6E5
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Zeb2
Gene Accession No. O60315
Gene Alias 9130203F04Rik; BOS_1771; D130016B08Rik; HRIHFB2411; HSPC082; KIAA0569; Sip1; SIP-1; SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; Zeb2; Zfhx1b; ZFX1B; Zfxh1b; zinc finger E-box binding homeobox 2; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b
Gene Symbols Zeb2
Host Species Mouse
Immunogen This SIP1 antibody was raised against a recombinant protein corresponding to amino acids 1-360 of human SIP1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9839
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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