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Tocris™ SIS3

Selective Smad3 inhibitor; inhibits TGF-betaR1 signaling

Manufacturer:  Tocris™ 5291/10

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Catalog No. 52-911-0


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Disclaimers:

For Research Use Only


Specifications

Description

Selective Smad3 inhibitor; attenuates TGF-β1-dependent Smad3 phosphorylation and DNA binding. Has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. Inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Also inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.
  • Chemical Name: 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride
  • Formula: C28H27N3O3.HCl
  • CAS Number: 521984-48-5
  • Solubility: Soluble to 100mM in DMSO
  • Purity: >98
Description & Specifications

Specifications

SIS3
>98
SIS3
489.99
10mg
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