Selective Smad3 inhibitor; inhibits TGF-betaR1 signaling
Manufacturer: Tocris 5291/10
DescriptionSelective Smad3 inhibitor; attenuates TGF-β1-dependent Smad3 phosphorylation and DNA binding. Has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. Inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Also inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.
- Chemical Name: 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride
- Formula: C28H27N3O3.HCl
- CAS Number: 521984-48-5
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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