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  8. SKI II, Tocris Bioscience™

SKI II, Tocris Bioscience™

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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
312636-16-1
C15H11ClN2OS
302.776
ZFGXZJKLOFCECI-UHFFFAOYSA-N
ski ii, 4-4-4-chlorophenyl-2-thiazolyl amino phenol, skiii, sphk-i2, 4-4-4-chlorophenyl-1,3-thiazol-2-yl amino phenol, sphingosine kinase inhibitor 2, 4-4-4-chlorophenyl thiazol-2-ylamino phenol, phenol, 4-4-4-chlorophenyl-2-thiazolyl amino, 3vzd
753704
4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl
This item is not returnable. View return policy
312636-16-1
C15H11ClN2OS
302.776
ZFGXZJKLOFCECI-UHFFFAOYSA-N
ski ii, 4-4-4-chlorophenyl-2-thiazolyl amino phenol, skiii, sphk-i2, 4-4-4-chlorophenyl-1,3-thiazol-2-yl amino phenol, sphingosine kinase inhibitor 2, 4-4-4-chlorophenyl thiazol-2-ylamino phenol, phenol, 4-4-4-chlorophenyl-2-thiazolyl amino, 3vzd
753704
4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl

Description

Selective non-lipid inhibitor of sphingosine kinase

Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).
Quantity 10 mg
Formula Weight 302.78
Percent Purity >98%
Chemical Name or Material SKI II

Safety and Handling

Recommended Storage : Store at -20°C