SOX10 Antibody (SOX10/1074), Alexa Fluor™ 647, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP259623AF647

Catalog No. NB008499

Description

SOX10 Monoclonal specifically detects SOX10 in Human, Mouse samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Product Image.

Specifications

• Antigen: SOX10
• Classification: Monoclonal
• Conjugate: Alexa Fluor 647
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: SOX10
• Immunogen: Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietary) (Uniprot: P56693 )
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Isotype: IgG2b κ

• Applications: Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Clone: SOX10/1074
• Dilution: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Alias: MGC15649, PCWH, SRY (sex determining region Y)-box 10, SRY-related HMG-box gene 10, transcription factor SOX-10, WS4C, WS4mouse, human homolog of
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Test Specificity: The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of ∼55kDa, identified as SOX10. This monoclonal antibody is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately-
• Content And Storage: Store at 4°C in the dark.