SOX10 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 104221AP150UL

Catalog No. 50-172-6295

Description

SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. SOX10 plays a central role in developing and maturing of glia. Specifically, SOX10 activates expression of myelin genes (such as DUSPP15 and MYRF) during oligodendrocyte (OL) maturation; thus, playing a central role in oligodendrocyte maturation and CNS myelination. Once induced MYRF cooperates with SOX10 to implement the myelination program. SOX10 is also a transcriptional activator of MITF acting synergistically with PAX3. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

Specifications

• Antigen: SOX10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SOX10
• Gene Alias: DOM, SOX10, Transcription factor SOX 10, WS2E, WS4
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20665, 29361, 6663
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 0.4 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: O55170, P56693, Q04888
• Gene Symbols: SOX10
• Immunogen: SOX10 Fusion Protein Ag0673
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG