Tocris™ SP 141

High affinity MDM2 inhibitor

Manufacturer: Tocris™ 5332/10

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Catalog No. 53-321-0

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For Research Use Only


    Description SP 141
    Quantity 10mg
    Product Type SP 141
    Molecular Weight 324.38
    Purity >98

    High affinity MDM2 inhibitor (Ki = 28nM); directly binds MDM2. Inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. Attenuates growth of breast cancer xenograft tumors. Cell permeable.

    • Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
    • Formula: C22H16N2O
    • CAS Number: 1253491-42-7
    • Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
    • Purity: >98

  • Description & Specifications

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