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Tocris™ SP 141

High affinity MDM2 inhibitor

Manufacturer:  Tocris™ 5332/10

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Catalog No. 53-321-0

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For Research Use Only



High affinity MDM2 inhibitor (Ki = 28nM); directly binds MDM2. Inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. Attenuates growth of breast cancer xenograft tumors. Cell permeable.
  • Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
  • Formula: C22H16N2O
  • CAS Number: 1253491-42-7
  • Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
  • Purity: >98
Description & Specifications


SP 141
SP 141
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