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SREBF1 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. p-7205968 Shop All Proteintech Group Inc Products
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50-172-9203 150 μL
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Catalog No. 50-172-9203 Supplier Proteintech Group Inc Supplier No. 140881AP150UL
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Description

Rabbit Polyclonal Antibody

This antibody can recognize the 125 kDa precursor form and the 68 kDa mature form of human SREBF1.

Sterol regulatory element-binding proteins (SREBPs) are transcription factors that are members of the basic helix-loop-helix leucine zipper family of DNA binding proteins. Three isoforms have been identified in mammalian tissues that vary in structure, regulation, and function. SREBP-1a and SREBP-1c (originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene. The third isoform is transcribed from a different gene, SREBP-2. SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, the SREBP protein is translocated to the Golgi and proteolytic cleavage occurs resulting in a mature transcriptionally active 60-78 kDa fragment. In liver and adipose tissues, SREBPs have a significant influence on lipid and cholesterol accumulation by inducing the transcription of genes involved in these processes. While SREBP-1 is thought to be more important in regulating the expression of genes involved in triglyceride synthesis and accumulation, SREBP-2 has been more closely linked to those involved in cholesterol synthesis and accumulation.

Specifications

Antigen SREBF1
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.54 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SREBF1
Gene Accession No. P36956
Gene Alias bHLHd1, SREBF1, SREBP 1, SREBP 1c, SREBP1
Gene Symbols SREBF1
Host Species Rabbit
Immunogen SREBF1 Fusion Protein Ag5219
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6720
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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