Tocris Bioscience™ ST 045849
O-GlcNAc transferase (OGT) inhibitor
Manufacturer: Tocris Bioscience™ 6775/10
DescriptionST 045849 is an O-GlcNAc transferase (OGT) inhibitor (IC50 = 53 μM). Reduces proliferation and viability of prostate cancer cells in vitro. Depletes intracellular alanine and decreases glucose consumption by cancer cells. Decreases markers of ER stress and apoptosis in pregnant diabetic mice and reduces neural tube defects in embryos from diabetic mice.
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