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ST2 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA523316
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Quantity:
100 μg
Catalog No. Quantity
PIPA523316 100 μg
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Catalog No. PIPA523316

Supplier: Thermo Scientific PA523316

Description

Rabbit Polyclonal Antibody

ST2 is a member of the interleukin 1 receptor family. Studies of ST2 in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. ST2 belongs to the interleukin-1 receptor family with three Ig-like C2-type (immunoglobulin-like) domains and a TIR domain. ST2 is a receptor for interleukin-33 (IL-33) which upon stimulation recruits the signaling molecules MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Reports also suggest its possible role in helper T-cell function as well as in cell growth. Three isoforms of ST2 have been reported where isoform C is a membrane form and isoform B is a secreted form. ST2 may be induced by proinflammatory stimuli, and may also be found in serum of autoimmune disease. Different isoforms are restricted to different tissues while high expression of this protein is evident in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ST2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.0 mg/mL
Conjugate Unconjugated
Gene IL1RL1
Gene Accession No. Q01638, P14719, Q62611
Gene Alias DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1, growth stimulation-expressed, homolog of mouse growth stimulation-expressed, interleukin 1 receptor-related protein, interleukin-1 receptor-like 1
Gene Symbols IL1RL1
Host Species Rabbit
Immunogen Synthetic peptide (36 CPRQGKPSYTVDWYYSQT 53) of ST2/IL1RL1 protein.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17082, 25556, 9173
Target Species Human, Mouse, Non-human Primate, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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