STMN4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-7655	Proteintech Group Inc 120271AP150UL	150 μL

Description

RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.

Specifications

• Antigen: STMN4
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P63042, P63043, Q9H169
• Gene ID (Entrez): 56471, 79423, 81551
• Immunogen: STMN4 Fusion Protein Ag2657
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: STMN4

• Concentration: 0.41 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: RB3, Stathmin 4, stathmin like 4, Stathmin like protein B3, STMN4
• Gene Symbols: Stmn4
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody