Synphilin 1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
FEPA5145488	Invitrogen™ PA5145488	20 μL
FEPA5145487	Invitrogen™ PA5145487	200 μL

Description

Parkinson is the second most common neurodegenerative disease after Alzheimer's. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease.

Specifications

• Antigen: Synphilin 1
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Rat
• Gene Accession No.: Q99ME3
• Gene ID (Entrez): 307309, 67847
• Immunogen: Recombinant Rat SNCaIP1 protein, Pro766-Leu963 (Accession #D3ZWQ5).
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Alias: 2810407O15Rik; 4933427B05Rik; Alpha-synuclein-interacting protein; BB104594; MGC39814; SNCAIP; Sph1; Synphilin 1; synphilin-1; synuclein alpha interacting protein; synuclein, alpha interacting protein; synuclein, alpha interacting protein (synphilin); SYPH1
• Gene Symbols: SNCAIP
• Isotype: IgG
• Purification Method: Affinity chromatography
• Gene: SNCAIP