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Syntaxin 1 Polyclonal Antibody, Invitrogen™

Catalog No. PA11042
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Quantity:
100 μg
Catalog No. Quantity
PA11042 100 μg
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Catalog No. PA11042

Supplier: Thermo Scientific PA11042

Description

Rabbit Polyclonal Antibody

PA1-1042 detects Syntaxin 1 in rat, mouse and bovine samples. PA1-1042 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ∽33 kDa protein representing Syntaxin 1 in rat, mouse and bovine brain tissue samples. The PA1-1042 immunogen is a synthetic peptide corresponding to residues V(22) T V D R D R F M D E F F E Q V E E I R(41) of rat Syntaxin 1. This sequence is conserved in mouse, human and bovine. The PA1-1042 immunizing peptide (Cat. No. PEP-278) is available for use in neutralization and control experiments.

Syntaxin 1 is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells and thought to be implicated in the regulation of synaptic neurotransmitter release. Syntaxin 1 interacts with several other proteins important for synaptic function (SNAP 25, Munc 18). Syntaxin 1 is the main target of one of the Botulinum neurotoxins (BoNT/C1) which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex. Syntaxin 1 is an essential component of the neurotransmitter release machinery, and regulation of Syntaxin 1 expression levels is thought to contribute to the mechanism underlying learning and memory.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Syntaxin 1
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene STX1A
Gene Accession No. P32850, Q16623, O35526, P32851
Gene Alias HPC-1, P35-1, STX1, SYN1A
Gene Symbols STX1A
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues V(22) T V D R D R F M D E F F E Q V E E I R(41) of rat Syntaxin 1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116470, 20907, 6804, 788566
Target Species Bovine, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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