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Tocris Bioscience™ T 5224
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Catalog No. p-200007269
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73-171-0 10 mg
73-175-0 50 mg
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Catalog No. 73-171-0 Supplier Tocris Bioscience™ Supplier No. 7317/10
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Description

Selective inhibitor of c-Fos/activator protein (AP)-1

T 5224 is a selective inhibitor of c-Fos/activator protein (AP)-1. It inhibits the DNA-binding and transactivation activities of AP-1, without affecting the activity of ATF2, C/EBPα, NF-κB/p65, MyoD, and Sp1 in vitro. In a mouse model, T 5224 prevents type II collagen-induced arthritis by reducing inflammatory cytokines (including interleukin 1β) and matrix-degrading MMPs.

Specifications

Chemical Name or Material 5-[4-(Cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]benzenepropanoic acid
CAS 530141-72-1
Quantity 10 mg
Target AP-1 Inhibitors
Molecular Formula C29H27NO8
Purity 0.98
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