Tacrolimus, 99+%, PROMO, Thermo Scientific Chemicals

Description

Tacrolimus also known as FK-506 or fujimycin, is a macrolide compound that exhibits immunosuppressant, neuroprotective, and neuroregenerative activities and can inhibit T-cell proliferation and activation.

General Description

• Tacrolimus is a macrolide isolated from Streptomyces tsukubaensis, that shows immunosuppressant, neuroprotective, and neuroregenerative activities, having the ability to block T-cell proliferation and activation in response to antigenic or mitogenic stimulation
• Tacrolimus interacts with the immunophilins cyclophilin and FKBP-12. Tacrolimus binds to the FKBP-12 protein (FK506 binding protein) and forms a complex with calcium-dependent proteins. This FKBP12-FK506 complex inhibits calcineurin phosphatase activity, resulting in decreased cytokine production, inhibition of T-lymphocyte signal transduction
• Tacrolimus also inhibits the transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF, all of which are involved in the early stages of T-cell activation
• This compound can also inhibit the release of pre-formed mediators from skin mast cells and basophils and downregulate the expression of FceRI on Langerhans cells

Application

• Tacrolimus has been studied in vitro to understand its impact on neutrophil production and/or survival
• It is applied to suppress the inflammation in ulcerative cells
• It is used as a research tool in chemically induced dimerization applications in biology
• It has been used in in vitro studies to investigate its effect on human monocyte-derived dentritic cells

Specifications

Chemical Identifiers

• CAS: 104987-11-3
• Molecular Formula: C₄₄H₆₉NO₁₂
• Synonym: FK-506; Fugimycin

• Quantity: 100 mg
• Content And Storage: -30°C to -10°C
• For Use With (Application): Interacts with the immunophilins cyclophilin and FKBP-12
• Melting Point: 120°C to 125°C
• Solubility: Freely soluble in DMSO or ethanol; Poorly soluble in water
• Product Type: Signal Transduction Reagent
• Form: Powder
• Assay: ≥99%

RUO - Research Use Only