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TAG-72 Antibody (B72.3 + CC49), DyLight 350, Novus Biologicals™
SDP

Catalog No. NBP234558UV Shop All R&D Systems Products
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Description

Mouse Monoclonal Antibody

TAG-72 Monoclonal specifically detects TAG-72 in Human, Rat, Bovine, Canine samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen TAG-72
Applications Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Classification Monoclonal
Clone B72.3 + CC49
Conjugate DyLight 350
Dilution Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Gene Alias CA 72-4, Protein TAG-72, tag 72, tag-72 Protein TAG-72
Host Species Mouse
Immunogen Membrane-enriched fraction of a human breast carcinoma liver metastasis (B72.3); Purified TAG-72 protein (CC49)
Molecular Weight of Antigen 220 kDa
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 182875
Test Specificity Recognizes an oncofetal antigen of 220kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This monoclonal antibody defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80% sensitivity and 93% specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of anti-TAG-72 and anti-GCDFP-15 is valuable in the diagnosis of apocrine carcinoma.
Target Species Human, Rat, Bovine, Canine
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG1 κ
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