TCF7 Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-3518	Active Motif 61580	10 μL
50-199-3517	Active Motif 61579	100 μL

Description

TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Specifications

• Antigen: TCF7
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P36402
• Gene ID (Entrez): 6932
• Immunogen: This antibody was raised against a peptide within the N-terminal region of human TCF7.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: TCF7

• Concentration: Lot-Specific
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Alias: AI465550; HMG-box; OTTHUMP00000159390; OTTHUMP00000159391; T cell factor-1; T-cell factor 1; T-cell specific; T-cell-specific transcription factor 1; Tcf1; Tcf-1; Tcf7; TCF-7; Transcription factor 7; transcription factor 7 (T-cell specific, HMG-box); transcription factor 7, T cell specific; transcription factor 7, T-cell specific
• Gene Symbols: TCF7
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody