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Invitrogen™ TCR V beta 5 Monoclonal Antibody (MEM-262)
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Catalog No. 01674993
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Catalog No. Quantity
01-674-993 100 μg
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Catalog No. 01-674-993 Supplier Invitrogen™ Supplier No. MA119020
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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope on beta chains of the TCR expressed by HPB-ALL cell line [carrying V(beta5.3)] and a small subset of peripheral blood T cells. This subset is larger than that recognized by other V(beta5.3)-specific antibodies. Functional Application: Activation.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
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Specifications

Antigen TCR V beta 5
Applications Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone MEM-262
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene TRB
Gene Accession No. P0DSE2
Gene Alias T cell receptor beta locus; TCR V beta5; TCRB; TCRV b5; TCRV beta 5; TRB; TRB@; Vb5; Vbeta5
Gene Symbols TRB
Host Species Mouse
Immunogen Human thymoma cell line HPB-ALL.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6957
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a
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Safety and Handling

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