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Invitrogen™ TDP-43 Polyclonal Antibody
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Catalog No. PIPA529949
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100 μL
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PIPA529949 100 μL
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Catalog No. PIPA529949 Supplier Invitrogen™ Supplier No. PA529949
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, HeLa, HepG2, Neuro2A, GL261, NIH-3T3, BCL-1, Raw264.7, PC-12, Rat-2, Rat brain. Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (83%), Xenopus laevis (91%), Chicken (95%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3'e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TDP-43
Applications ChIP sequencing (ChIP-seq), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, RNA Immunoprecipitation, Immunocytochemistry
Classification Polyclonal
Concentration 0.63 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene TARDBP
Gene Accession No. Q13148, Q921F2
Gene Alias 1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Gene Symbols TARDBP
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human TDP43. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 230908, 23435, 298648
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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