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TdT Monoclonal Antibody (7UNA8U6), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
$139.50 - $346.50
Specifications
| Antigen | TdT |
|---|---|
| Clone | 7UNA8U6 |
| Concentration | 0.5 mg/mL |
| Applications | Immunohistochemistry (Paraffin), Western Blot |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-255-0878
|
Invitrogen™
14973980 |
25 μg |
Each
for $139.50
Save 25% Reg : |
|
|||||
|
14-973-982
|
Invitrogen™
14973982 |
100 μg |
Each
for $346.50
Save 25% Reg : |
|
|||||
Description
The MAb 7UNA8U6 reacts with human, mouse, and rat TdT. TdT, or terminal-deoxynucleotidyl transferase, is a 60 kDa polymerase responsible for the template-independent addition of N-nucleotides at gene segment junctions of developing lymphocytes. Expression is found in the nucleus of immature lymphocytes but not in mature lymphocytes or non-lymphoid cells. TdT plays a critical role during TCR and Ig gene rearrangement and functions to increase the diversity of the lymphocyte repertoire through the addition of N-nucleotides onto the ends of newly formed P-nucleotides. After positive selection, expression of TdT becomes decreased or absent. Expression of TdT has been shown to be present in lymphoma or lymphoblastic leukemia cells.
Terminal Deoxynucleotidyl Transferase (TdT) is a DNA polymerase located in the cell nucleus which catalyses the polymerization of deoxynucleotides at the 3' hydroxyl ends of oligo or polydeoxynucleotide initiators and functions without a template. TdT is considered to be a highly specific marker for the diagnosis and classification of acute lymphoblastic lymphoma/leuksemias. The determination of TdT expression is most valuable when it is different to differentiate histologically between lymphoblastic lymphoma and Burkitt's lymphoma.Specifications
| TdT | |
| 0.5 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| Deoxynucleotidyltransferase terminal; deoxynucleotidyltransferase, terminal; DNA nucleotidylexotransferase; Dntt; Nucleosidetriphosphate DNA Deoxynucleotidylexotransferase; nucleosidetriphosphate:DNA deoxynucleotidylexotransferase; TDT; Terminal addition enzyme; terminal deoxynucleotidyl transferase; terminal deoxynucleotidyltransferase; terminal deoxyribonucleotidyltransferase; terminal transferase | |
| DNTT | |
| Primary | |
| 4°C | |
| DNTT |
| 7UNA8U6 | |
| Immunohistochemistry (Paraffin), Western Blot | |
| Unconjugated | |
| Mouse | |
| Human, Mouse, Rat | |
| P04053, P09838 | |
| 1791, 21673, 294051 | |
| IgG1 κ | |
| Affinity Chromatography | |
| Antibody |
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