Invitrogen™ TEF1 Polyclonal Antibody

Catalog No.	Quantity
PIPA566495	100 μL

Catalog No. PIPA566495

Supplier: Invitrogen™ PA566495

Description

Rabbit Polyclonal Antibody

Immunogen sequence: IEPSSWSGSES PAENMERMSD SADKPIDND Highest antigen sequence identity to the following orthologs - mouse 50%, rat 50%.

TEF1 (Transcriptional enhancer factor 1), a member of the TEA/ATTS domain family, is a nuclear protein that is expressed in numerous cell types and plays a role in controlling the expression of numerous genes. TEF family members have a highly conserved DNA-binding domain TEF-1 binds to GT-IIC, SphI/II and M-CAT. TEF-1 also binds to the proximal regulatory element (PRE) of transforming growth factor-alpha, a member of the EGF family that is overexpressed in many types of cancer. Furthermore, TEF-1 represses transcription in placental cells. In vitro, TEF-1 is phosphorylated by several PKC isozymes. TEF-1 is phosphorylated in vivo at serine and threonine residues. Phosphorylation of TEF-1, both in vivo and in vitro, results in a reduction in its DNA-binding capability, which suggests a potential role for TEF-1 in PKC inhibition. TEF-1 also complexes with larger tumor antigen (TAg), and may thus have a role in tumorigenesis. Dimerization of TEF-1 may be important for TEF-1 to function as a regulator of gene transcription.

Specifications

• Antigen: TEF1
• Applications: ChIP Assay, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Tead1
• Gene Accession No.: P28347
• Gene Alias: 2610024B07Rik; AA; B230114H05Rik; Gtrgeo5; mTEF-1; N TEAD1; NTEF1; NTEF-1; protein GT-IIC; REF1; Tcf13; TCF-13; TEA domain family member 1; TEA domain family member 1 (SV40 transcriptional enhancer factor); TEA domain transcription factor 1; TEAD1; TEAD-1; TEF1; TEF-1; Transcription factor 13; transcriptional enhancer factor 1; transcriptional enhancer factor TEF-1
• Gene Symbols: Tead1
• Host Species: Rabbit
• Immunogen: Recombinant Human TEF1. Recombinant protein control fragment (Product #RP-107166).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7003
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov