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Tocris Bioscience™ Thiazovivin
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Catalog No. 384510
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38-451-0 10 mg
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Catalog No. 38-451-0 Supplier Tocris Bioscience™ Supplier No. 3845/10
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Description

ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Thiazovivin is a selective, cell-permeable Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (IC50 = 0.5 μM). Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Thiazovivin improves the survival of human embryonic stem cells (hESCs) upon trypsinization and increases cell adhesion through the regulation of E-cadherin and significantly improves direct reprogramming efficiency. In combination with Valproic acid, sodium salt (Cat. No. 2815), Purmorphamine (Cat. No. 4551) and A 83-01 (Cat. No. 2939), Thiazovivin can be used to directly reprogram mouse embryonic fibroblasts into chemically induced neural stem cells.

Chemical Identifiers

CAS 1226056-71-8
Molecular Formula C15H13N5OS

Specifications

Quantity 10 mg
Formula Weight 311.36
Purity 98%
Molecular Weight (g/mol) 311.363
Chemical Name or Material Thiazovivin

Safety and Handling

Recommended Storage Store at -20°C
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